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amorphous trehalose dihydrate by cryogenic milling

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(PDF) Distinct effects of sucrose and trehalose on protein ...

Distinct effects of sucrose and trehalose on protein stability during supercritical fluid drying and freeze-drying. European Journal of Pharmaceutical Sciences, 2006. Gerard Hofland.

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Estimation of crystallinity of trehalose dihydrate ...

Sep 01, 2012 · Read "Estimation of crystallinity of trehalose dihydrate microspheres by usage of terahertz time‐domain spectroscopy, Journal of Pharmaceutical Sciences" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at .

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Direct Crystal to Glass Transformations of Trehalose ...

Abstract In this paper, we present a short review of the different solid state vitrification routes of trehalose recently identified by our group. Three routes are investigated: the mechanical milling of the stable crystalline anhydrous form, the rapid dehydration of the dihydrate form, and the sub Tg annealing of the polymorphic form α.

  • Authors: J F Willart · M Descamps · Vincent CaronAffiliation: University of LilleAbout: X-ray crystallography · Differential scanning calorimetry · Heat capacity · PolymorphismGet Price

Mechanically Induced Amorphization of Drugs: A Study of ...

At higher milling rates, it is likely that most of the nuclei are forced back into the amorphous phase resulting in a fewer number of nuclei. Clearly, milling will result in the creation of a large amount of surface on the amorphous solid which can increase the extent of crystallization occurring around the glass transition temperature.

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Andrew Megarry - Associate Principal Scientist ...

The aim of the project was to create and stabilise amorphous pharmaceutical formulations using cryogenic milling. We found that cryogenic milling was a mild and widely applicable technique for ...

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Structure in Dehydrated Trehalose Dihydrate—Evaluation of ...

Aug 23, 2006 · An increase in the temperature of dehydration resulted in a decrease in lattice order. In agreement with earlier findings, the ordered regions in the dehydrated lattice ({left( {{text{T}}_{{text{ $ alpha $ }}} } right)}) converted to the dihydrate at much lower RH values than amorphous trehalose. However, the lattice order in the ...

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Critical Considerations for the Qualitative and ...

Critical Considerations for the Qualitative and Quantitative Determination of Process-Induced Disorder in Crystalline Solids Ann Newman 1,* and George Zografi 2

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Effect of Aging on the Physical Properties of Amorphous ...

Effect of Aging on the Physical Properties of Amorphous Trehalose. Pharmaceutical Research, 2000. Raj Suryanarayanan. Rahul Surana. Raj Suryanarayanan. Rahul Surana. Download with Google Download with Facebook or download with email.

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Amorphous trehalose dihydrate by cryogenic milling ...

We have demonstrated that the crystal to glass transformation for trehalose dihydrate is possible using cryogenic milling. This is the first reported example of cryogenic milling (a mild and widely applicable technique) applied to generating amorphous hydrates.

Characterization of the phase transitions of trehalose ...

Jun 12, 2000 · Characterization of the phase transitions of trehalose dihydrate on heating and subsequent dehydration. Authors. Lynne S. Taylor, ... Amorphous trehalose dihydrate by cryogenic milling, Carbohydrate Research, 2011, 346, 8, 1061CrossRef;

  • Published in: Journal of Pharmaceutical Sciences · 1998Authors: Lynne S Taylor · Peter YorkAffiliation: University of BradfordAbout: Hydrate · Phase transition · Particle size · Trehalose · X-ray crystallography · Dehydr.Get Price

The Amorphous Form in Drug Development - PolyCrystalline

and a dihydrate L. Yu. Amorphous Pharmaceutical Solids: preparation, characterization and stabilization. Adv. Drug Del. Rev., 2001, 27-42. Amorphous treahlose T g about 120°C Amorphous trehalose can be obtained by quenching of the melt or by milling of the #-form but not by milling of the dihydrate Amorphous treahlose dihydrate T g about 20°C

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D-(+)-Trehalose (D-Trehalose) | Saccharides and Glycoside ...

D-(+)-Trehalose, isolated from Saccharomyces cerevisiae, can be used as a food ingredient and pharmaceutical excipient. - Mechanism of Action & Protocol.

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cost of cryogenic grinding - ezikorestaurant

Home Milling Grinding cryogenic fine mill cost, air products showcases polarfit, retsch cryogenic jar mill retsch cryogenic mill from cole parmer. Free Quote. cryogenic fine mill cost. Belt Conveyor. Mining delivers the world's most comprehensive range of Heavy-duty conveyor belts. Base on more than 30 years of experience in development . Get Price

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Jeffery Burley | University of Oxford - Academia.edu

It has been reported that room temperature milling does not lead to the formation of amorphous trehalose dihydrate. This paper reports the behaviour of trehalose dihydrate upon milling at cryogenic temperatures as studied by DSC, TGA, XRPD and Raman spectroscopy.

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Polymorphic Amorphous and Crystalline Forms of Trehalose ...

A characterization has been carried out on the dihydrate and anhydrous crystalline form of trehalose (α-d-Glucopyranosyl-α-d-glucopyranoside), which is considered anomalous in respect to other disaccharides in conferring to organisms the ability to be dried at high temperatures and then to rehydrate without damaging cellular functions. The thermal dehydration of the dihydrate trehalose, Th ...

Jonathan Burley - The University of Nottingham

formation and stabilisation of amorphous materials, to produce new highly soluble medicines; ... Amorphous trehalose dihydrate by cryogenic milling. Carbohydrate research. 346(8), 1061-4. ... Amodiaquinium dichloride dihydrate from laboratory powder diffraction data Acta Crystallographica. Section E: Structure Reports Online.

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Characterization of the phase transitions of trehalose ...

Characterization of the phase transitions of trehalose dihydrate on heating and subsequent dehydration. Authors. Lynne S. Taylor, ... Amorphous trehalose dihydrate by cryogenic milling, Carbohydrate Research, 2011, 346, 8, 1061CrossRef;

  • Published in: Journal of Pharmaceutical Sciences · 1998Authors: Lynne S Taylor · Peter YorkAffiliation: University of BradfordAbout: Hydrate · Phase transition · Particle size · Trehalose · X-ray crystallography · Dehydra.Get Price

trehalose, 99-20-7 - The Good Scents Company

PubMed:Amorphous trehalose dihydrate by cryogenic milling. PubMed:Population size drives industrial Saccharomyces cerevisiae alcoholic fermentation and is under genetic control. PubMed:Trehalose: current use and future applications. PubMed:The aggregative stability of β-lactoglobulin in glassy mixtures with sucrose, trehalose and dextran.

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Amorphous trehalose dihydrate by cryogenic milling ...

Jun 01, 2011 · It has been reported that room temperature milling does not lead to the formation of amorphous trehalose dihydrate. This paper reports the behaviour of trehalose dihydrate upon milling at cryogenic temperatures as studied by DSC, TGA, XRPD and Raman spectroscopy.

British Library EThOS: Cryomilling for formulation

Phthalic acid, isophthalic acid and terephthalic acid, individual and pair mixtures, are crystalline organic non medicinal compounds, which have been used for the first time as model compounds to investigate whether cryogenic milling can induce crystal to amorphous transformation and if the preparation of pair mixtures could affect the ...

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Raman Spectroscopy - University of Nottingham

Raman spectroscopy is a non-invasive optical technique used to determine the chemical identity and state of a sample by its unique vibrational (molecular) modes. Inelastic (loss or gain of energy) scattering of light from the sample is measured, with distinct shifts in the energy of the scattered photons being representative of the sample ...

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